Yes, the Club Keyboard is fully programmable so you can change your key programming at any time. You can update to any key mapping by following the instructions on the Key Programming page. There are a few options to change the labels on your keyboard to match the new programming. You can order key labels to stick on below any button you want to change. You can order an overlay which sits on top of the keyboard with the new layout, and can also be stuck on with the adhesive backing that is included. You can also order a new faceplate with or without the buttons and wiring depending on your comfort level with removing buttons and wires and reconnected them together in the new faceplate.